InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRMP

Summary

InnateDB Protein

IDBP-602446.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRMP

Protein Name

lymphoid-restricted membrane protein

Synonyms

JAW1;

Species

Homo sapiens

Ensembl Protein

ENSP00000446496

InnateDB Gene

IDBG-23751 (LRMP)

Protein Structure

UniProt Annotation

Function

Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion.

Subcellular Localization

Processed lymphoid-restricted membrane protein: Cytoplasm {ECO:0000250}.Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Chromosome {ECO:0000250}. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles. {ECO:0000269PubMed:16739114, ECO:0000269PubMed:8021504}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0002376	immune system process
GO:0006903	vesicle targeting
GO:0006906	vesicle fusion
GO:0007338	single fertilization

Cellular Component

GO:0000922	spindle pole
GO:0005635	nuclear envelope
GO:0005694	chromosome
GO:0005789	endoplasmic reticulum membrane
GO:0005815	microtubule organizing center
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane