InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF7

Summary

InnateDB Protein

IDBP-602624.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF7

Protein Name

fibroblast growth factor 7

Synonyms

HBGF-7; KGF;

Species

Homo sapiens

Ensembl Protein

ENSP00000453048

InnateDB Gene

IDBG-11473 (FGF7)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. {ECO:0000269PubMed:16597617, ECO:0000269PubMed:8663044}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Epithelial cell.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042056	chemoattractant activity

Biological Process

GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008544	epidermis development
GO:0009611	response to wounding
GO:0010463	mesenchymal cell proliferation
GO:0010838	positive regulation of keratinocyte proliferation
GO:0031532	actin cytoskeleton reorganization
GO:0034394	protein localization to cell surface
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0051549	positive regulation of keratinocyte migration
GO:0051781	positive regulation of cell division
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0061033	secretion by lung epithelial cell involved in lung growth