InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGPAT3

Summary

InnateDB Protein

IDBP-602888.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGPAT3

Protein Name

1-acylglycerol-3-phosphate O-acyltransferase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000443510

InnateDB Gene

IDBG-4929 (AGPAT3)

Protein Structure

UniProt Annotation

Function

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. {ECO:0000269PubMed:21173190}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver. {ECO:0000269PubMed:21173190}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0016024	CDP-diacylglycerol biosynthetic process
GO:0019432	triglyceride biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process

Cellular Component

GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane