InnateDB Protein
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IDBP-602945.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DBI
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Protein Name
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diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
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Synonyms
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ACBD1; ACBP; CCK-RP; EP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000440698
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InnateDB Gene
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IDBG-67980 (DBI)
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Protein Structure
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Function |
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
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Subcellular Localization |
Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. {ECO:0000269PubMed:16055366, ECO:0000269PubMed:21698759}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000582
Acyl-CoA-binding protein, ACBP
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PFAM |
PF00887
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PRINTS |
PR00689
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P07108
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PhosphoSite |
PhosphoSite-P07108
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TrEMBL |
B8ZWD9
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UniProt Splice Variant |
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Entrez Gene |
1622
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UniGene |
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RefSeq |
NP_001269565
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HUGO |
HGNC:2690
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OMIM |
125950
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CCDS |
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HPRD |
08832
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IMGT |
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EMBL |
AC016736
AM000001
BC006466
BC062996
CH471103
CR456956
FM213123
FM213124
FM213125
FM213126
FM213127
FM213128
FM213129
FM213130
FM213131
M14200
M15887
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GenPept |
AAA35788
AAA52171
AAH62996
AAY14873
CAG33237
CAJ00736
CAR82405
CAR82406
CAR82407
CAR82408
CAR82409
CAR82410
CAR82411
CAR82412
CAR82414
EAW95214
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