Version 5.4
Homo sapiens Protein: FGD4
Summary
InnateDB Protein IDBP-603134.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGD4
Protein Name FYVE, RhoGEF and PH domain containing 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000446695
InnateDB Gene IDBG-26267 (FGD4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR000306 FYVE zinc finger
IPR001849 Pleckstrin homology domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF00621
PF01363
PF00169
PRINTS
PIRSF
SMART SM00325
SM00064
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F8W1R0
UniProt Splice Variant
Entrez Gene 121512
UniGene Hs.117835
RefSeq
HUGO HGNC:19125
OMIM 611104
CCDS
HPRD 16891
IMGT
EMBL AC084824 AC087245 AC090440 AC090677
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca