InnateDB Protein
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IDBP-603250.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SSX2IP
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Protein Name
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synovial sarcoma, X breakpoint 2 interacting protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000432261
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InnateDB Gene
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IDBG-99995 (SSX2IP)
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Protein Structure
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Function |
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin. Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. {ECO:0000250, ECO:0000269PubMed:23816619}.
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Subcellular Localization |
Cell junction, adherens junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Not found at cell-matrix AJs. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
35
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR021622
Afadin/alpha-actinin-binding
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PFAM |
PF11559
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y2D8
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PhosphoSite |
PhosphoSite-Q9Y2D8
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TrEMBL |
C9JIX7
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UniProt Splice Variant |
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Entrez Gene |
117178
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UniGene |
Hs.627106
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RefSeq |
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HUGO |
HGNC:16509
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OMIM |
608690
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CCDS |
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HPRD |
10566
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IMGT |
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EMBL |
AB023140
AC114482
AK292475
AK294057
AL133046
AY367055
BC033637
BC064389
CH471097
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GenPept |
AAH33637
AAH64389
AAQ72373
BAA76767
BAF85164
BAG57404
CAB61373
EAW73224
EAW73226
EAW73227
EAW73228
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