Version 5.4
Homo sapiens Protein: CSRP2
Summary
InnateDB Protein IDBP-603346.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSRP2
Protein Name cysteine and glycine-rich protein 2
Synonyms CRP2; LMO5; SmLIM;
Species Homo sapiens
Ensembl Protein ENSP00000450056
InnateDB Gene IDBG-49092 (CSRP2)
Protein Structure
UniProt Annotation
Function Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in the aorta, but not in heart and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008270 zinc ion binding
Biological Process
GO:0007275 multicellular organismal development
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16527
PhosphoSite PhosphoSite-Q16527
TrEMBL A0A024RBB5
UniProt Splice Variant
Entrez Gene 1466
UniGene Hs.603478
RefSeq
HUGO HGNC:2470
OMIM 601871
CCDS CCDS9015
HPRD 03523
IMGT
EMBL BC000992 BT019913 CH471054 U46006 U57646 U95018
GenPept AAC27344 AAC51753 AAC51755 AAH00992 AAV38716 EAW97336 EAW97337

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca