InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL15RA

Summary

InnateDB Protein

IDBP-604071.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL15RA

Protein Name

interleukin 15 receptor, alpha

Synonyms

CD215;

Species

Homo sapiens

Ensembl Protein

ENSP00000431529

InnateDB Gene

IDBG-50371 (IL15RA)

Protein Structure

UniProt Annotation

Function

High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK. {ECO:0000269PubMed:11714793, ECO:0000269PubMed:8530383}.

Subcellular Localization

Membrane {ECO:0000269PubMed:10480910}; Single-pass type I membrane protein {ECO:0000269PubMed:10480910}. Nucleus membrane {ECO:0000269PubMed:10480910}; Single-pass type I membrane protein {ECO:0000269PubMed:10480910}. Note=Mainly found associated with the nuclear membrane.Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space.

Disease Associations

Tissue Specificity

Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures. {ECO:0000269PubMed:10480910, ECO:0000269PubMed:12114302, ECO:0000269PubMed:8530383}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0019221	cytokine-mediated signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031965	nuclear membrane