Homo sapiens Protein: NHP2 | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||
InnateDB Protein | IDBP-60780.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | NHP2 | ||||||||||||||||||
Protein Name | NHP2 ribonucleoprotein homolog (yeast) | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000274606 | ||||||||||||||||||
InnateDB Gene | IDBG-60778 (NHP2) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269PubMed:15044956}. | ||||||||||||||||||
Subcellular Localization | Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies). | ||||||||||||||||||
Disease Associations | Dyskeratosis congenita, autosomal recessive, 2 (DKCB2) [MIM:613987]: A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. {ECO:0000269PubMed:18523010}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver. {ECO:0000269PubMed:12020816}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
Biological Process |
|
||||||||||||||||||
Cellular Component |
|
||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR002415
H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45 IPR018492 Ribosomal protein L7Ae/L8/Nhp2 family IPR029064 50S ribosomal protein L30e-like |
||||||||||||||||||
PFAM |
PF01248
|
||||||||||||||||||
PRINTS |
PR00883
PR00881 |
||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9NX24 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9NX24 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 55651 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NP_060308 | ||||||||||||||||||
HUGO | HGNC:14377 | ||||||||||||||||||
OMIM | 606470 | ||||||||||||||||||
CCDS | CCDS4432 | ||||||||||||||||||
HPRD | 07570 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC136632 AF161404 AF401219 AJ293309 AK000486 BC000009 BC006387 CR457238 | ||||||||||||||||||
GenPept | AAF28964 AAH00009 AAH06387 AAL02175 BAA91198 CAC08452 CAG33519 | ||||||||||||||||||