Version 5.4
Homo sapiens Protein: PCGF3
Summary
InnateDB Protein IDBP-6095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCGF3
Protein Name polycomb group ring finger 3
Synonyms DONG1; RNF3; RNF3A;
Species Homo sapiens
Ensembl Protein ENSP00000354724
InnateDB Gene IDBG-6093 (PCGF3)
Protein Structure
UniProt Annotation
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Subcellular Localization Nucleus {ECO:0000269PubMed:21282530}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0031519 PcG protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
IPR029071 Ubiquitin-related domain
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3KNV8
PhosphoSite PhosphoSite-Q3KNV8
TrEMBL C9JYD0
UniProt Splice Variant
Entrez Gene 10336
UniGene Hs.707307
RefSeq NP_006306
HUGO HGNC:10066
OMIM
CCDS CCDS3339
HPRD 11515
IMGT
EMBL AC107464 AC139887 AJ001019 AK300290 BC107061 CH471131
GenPept AAI07062 BAG62047 CAA04477 EAW82652 EAW82653 EAW82656

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca