InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHKA

Summary

InnateDB Protein

IDBP-61244.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHKA

Protein Name

choline kinase alpha

Synonyms

CHK; CK; CKI; EK;

Species

Homo sapiens

Ensembl Protein

ENSP00000265689

InnateDB Gene

IDBG-61242 (CHKA)

Protein Structure

UniProt Annotation

Function

Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. {ECO:0000269PubMed:19915674}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004103	choline kinase activity
GO:0004104	cholinesterase activity
GO:0004305	ethanolamine kinase activity
GO:0004871	signal transducer activity
GO:0005524	ATP binding
GO:0008144	drug binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0033265	choline binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006657	CDP-choline pathway
GO:0006869	lipid transport
GO:0007165	signal transduction
GO:0016310	phosphorylation
GO:0019695	choline metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process