Version 5.4
Homo sapiens Protein: BAX
Summary
InnateDB Protein IDBP-61469.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAX
Protein Name BCL2-associated X protein
Synonyms BCL2L4;
Species Homo sapiens
Ensembl Protein ENSP00000293288
InnateDB Gene IDBG-61459 (BAX)
Protein Structure
UniProt Annotation
Function Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. {ECO:0000269PubMed:10772918, ECO:0000269PubMed:16113678, ECO:0000269PubMed:18948948, ECO:0000269PubMed:21199865, ECO:0000269PubMed:8358790, ECO:0000269PubMed:8521816}.
Subcellular Localization Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Colocalizes with 14- 3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.Isoform Beta: Cytoplasm.Isoform Gamma: Cytoplasm.Isoform Delta: Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. {ECO:0000269PubMed:10772918, ECO:0000269PubMed:11912183}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 139 [view]
Protein-Protein 125 [view]
Protein-DNA 14 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0015267 channel activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051434 BH3 domain binding
Biological Process
GO:0001541 ovarian follicle development
GO:0001764 neuron migration
GO:0001776 leukocyte homeostasis
GO:0001777 T cell homeostatic proliferation
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001822 kidney development
GO:0001836 release of cytochrome c from mitochondria
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001974 blood vessel remodeling
GO:0002262 myeloid cell homeostasis
GO:0002352 B cell negative selection
GO:0002358 B cell homeostatic proliferation
GO:0002904 positive regulation of B cell apoptotic process
GO:0006687 glycosphingolipid metabolic process
GO:0006808 regulation of nitrogen utilization
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006927 transformed cell apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0007548 sex differentiation
GO:0008053 mitochondrial fusion
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008637 apoptotic mitochondrial changes
GO:0009566 fertilization
GO:0009611 response to wounding
GO:0009636 response to toxic substance
GO:0009651 response to salt stress
GO:0009791 post-embryonic development
GO:0010212 response to ionizing radiation
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0010332 response to gamma radiation
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0016032 viral process
GO:0021854 hypothalamus development
GO:0021987 cerebral cortex development
GO:0032091 negative regulation of protein binding
GO:0032461 positive regulation of protein oligomerization
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0032976 release of matrix enzymes from mitochondria
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0034644 cellular response to UV
GO:0035108 limb morphogenesis
GO:0035234 ectopic germ cell programmed cell death
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043496 regulation of protein homodimerization activity
GO:0043497 regulation of protein heterodimerization activity
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045136 development of secondary sexual characteristics
GO:0046666 retinal cell programmed cell death
GO:0048087 positive regulation of developmental pigmentation
GO:0048147 negative regulation of fibroblast proliferation
GO:0048515 spermatid differentiation
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0048678 response to axon injury
GO:0048872 homeostasis of number of cells
GO:0048873 homeostasis of number of cells within a tissue
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051402 neuron apoptotic process
GO:0051726 regulation of cell cycle
GO:0051881 regulation of mitochondrial membrane potential
GO:0060011 Sertoli cell proliferation
GO:0060041 retina development in camera-type eye
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0060068 vagina development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242 thymocyte apoptotic process
GO:0070584 mitochondrion morphogenesis
GO:0071310 cellular response to organic substance
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902262 apoptotic process involved in patterning of blood vessels
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:1902512 positive regulation of apoptotic DNA fragmentation
GO:1990009 retinal cell apoptotic process
GO:1990117 B cell receptor apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005757 mitochondrial permeability transition pore complex
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0046930 pore complex
GO:0070062 extracellular vesicular exosome
GO:0097136 Bcl-2 family protein complex
GO:0097144 BAX complex
Protein Structure and Domains
PDB ID
InterPro IPR002475 Bcl2-like
IPR026298 Blc2 family
PFAM PF00452
PRINTS PR01862
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q07812
PhosphoSite PhosphoSite-Q07812
TrEMBL Q9UEI8
UniProt Splice Variant
Entrez Gene 581
UniGene
RefSeq NP_004315
HUGO HGNC:959
OMIM 600040
CCDS CCDS12744
HPRD 02498
IMGT
EMBL AF007826 AF008195 AF008196 AF247393 AF250190 AF339054 AJ417988 AJ586909 AK291076 AY217036 BC014175 CH471177 HQ889830 L22473 L22474 L22475 U19599
GenPept AAA03619 AAA03620 AAA03621 AAC50142 AAD01415 AAD22706 AAF71267 AAF82094 AAH14175 AAL73333 AAO22992 ADZ05507 BAF83765 CAD10744 CAE52909 EAW52417 EAW52418

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca