InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AADAC

Summary

InnateDB Protein

IDBP-61655.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AADAC

Protein Name

arylacetamide deacetylase (esterase)

Synonyms

CES5A1; DAC;

Species

Homo sapiens

Ensembl Protein

ENSP00000232892

InnateDB Gene

IDBG-61653 (AADAC)

Protein Structure

UniProt Annotation

Function

Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000269PubMed:17936933, ECO:0000269PubMed:19339378, ECO:0000269PubMed:22207054, ECO:0000269PubMed:22415931, ECO:0000269PubMed:23542347}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder. {ECO:0000269PubMed:19339378, ECO:0000269PubMed:22207054, ECO:0000269PubMed:22415931}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004806	triglyceride lipase activity
GO:0016298	lipase activity
GO:0016787	hydrolase activity
GO:0017171	serine hydrolase activity
GO:0019213	deacetylase activity
GO:0052689	carboxylic ester hydrolase activity