InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEFA3

Summary

InnateDB Protein

IDBP-6166.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEFA3

Protein Name

defensin, alpha 3, neutrophil-specific

Synonyms

DEF1; DEF3; DEFA2; HNP-1; HNP-3; HNP3; HP-1; HP-3; HP1; HP3; MRS;

Species

Homo sapiens

Ensembl Protein

ENSP00000328359

InnateDB Gene

IDBG-402318 (DEFA3)

Protein Structure

UniProt Annotation

Function

Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. {ECO:0000269PubMed:15616305, ECO:0000269PubMed:15894545, ECO:0000269PubMed:17452329, ECO:0000269PubMed:2006422}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0002227	innate immune response in mucosa
GO:0006805	xenobiotic metabolic process
GO:0006952	defense response
GO:0009615	response to virus
GO:0019731	antibacterial humoral response
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0031640	killing of cells of other organism
GO:0042742	defense response to bacterium
GO:0045087	innate immune response
GO:0050830	defense response to Gram-positive bacterium
GO:0050832	defense response to fungus
GO:0051607	defense response to virus