InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAP2B

Summary

InnateDB Protein

IDBP-61906.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAP2B

Protein Name

RAP2B, member of RAS oncogene family

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000319096

InnateDB Gene

IDBG-61904 (RAP2B)

Protein Structure

UniProt Annotation

Function

Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. {ECO:0000269PubMed:11877431, ECO:0000269PubMed:15143162, ECO:0000269PubMed:16540189}.

Subcellular Localization

Recycling endosome membrane {ECO:0000269PubMed:16540189}; Lipid-anchor {ECO:0000269PubMed:16540189}; Cytoplasmic side {ECO:0000269PubMed:16540189}. Note=Associated with red blood cells-released vesicles.

Disease Associations

Tissue Specificity

Expressed in red blood cells (at protein level). {ECO:0000269PubMed:16540189}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030336	negative regulation of cell migration
GO:0031954	positive regulation of protein autophosphorylation
GO:0032486	Rap protein signal transduction
GO:0061097	regulation of protein tyrosine kinase activity

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt