InnateDB Protein
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IDBP-61951.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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STOML2
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Protein Name
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stomatin (EPB72)-like 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000348886
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InnateDB Gene
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IDBG-61949 (STOML2)
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Protein Structure
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Function |
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO:0000269PubMed:17121834, ECO:0000269PubMed:18641330, ECO:0000269PubMed:19597348, ECO:0000269PubMed:19944461, ECO:0000269PubMed:21746876, ECO:0000269PubMed:22623988}.
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Subcellular Localization |
Mitochondrion inner membrane. Mitochondrion intermembrane space. Cell membrane; Peripheral membrane protein. Membrane raft; Peripheral membrane protein. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level). {ECO:0000269PubMed:10713127, ECO:0000269PubMed:11435687, ECO:0000269PubMed:18641330}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
35
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001107
Band 7 protein
IPR001972
Stomatin family
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PFAM |
PF01145
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PRINTS |
PR00721
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PIRSF |
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SMART |
SM00244
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UJZ1
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PhosphoSite |
PhosphoSite-Q9UJZ1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
30968
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UniGene |
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RefSeq |
NP_038470
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HUGO |
HGNC:14559
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OMIM |
608292
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CCDS |
CCDS6577
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HPRD |
16310
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IMGT |
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EMBL |
AC004472
AF161458
AF190167
AF282596
AK027405
AK223102
AK303883
AL353795
BC002442
BC003025
BC010152
BC014990
CH471071
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GenPept |
AAC07983
AAF09142
AAF29073
AAF91466
AAH02442
AAH03025
AAH10152
AAH14990
BAB55091
BAD96822
BAG64819
CAH70998
EAW58395
EAW58396
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