InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UXT

Summary

InnateDB Protein

IDBP-61975.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UXT

Protein Name

ubiquitously-expressed transcript

Synonyms

ART-27; STAP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000327797

InnateDB Gene

IDBG-61973 (UXT)

Protein Structure

UniProt Annotation

Function

Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region. {ECO:0000269PubMed:11827465, ECO:0000269PubMed:11854421, ECO:0000269PubMed:16221885, ECO:0000269PubMed:17554592, ECO:0000269PubMed:17620405, ECO:0000269PubMed:17635584, ECO:0000269PubMed:21730289}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus. {ECO:0000269PubMed:11854421, ECO:0000269PubMed:16221885, ECO:0000269PubMed:17635584, ECO:0000269PubMed:21730289}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	31 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0048487	beta-tubulin binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000226	microtubule cytoskeleton organization
GO:0006351	transcription, DNA-templated
GO:0006457	protein folding
GO:0047497	mitochondrion transport along microtubule
GO:0051297	centrosome organization

Cellular Component

GO:0000930	gamma-tubulin complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005856	cytoskeleton
GO:0016272	prefoldin complex