InnateDB Protein
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IDBP-61977.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UXT
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Protein Name
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ubiquitously-expressed transcript
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Synonyms
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ART-27; STAP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000337393
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InnateDB Gene
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IDBG-61973 (UXT)
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Protein Structure
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Function |
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region. {ECO:0000269PubMed:11827465, ECO:0000269PubMed:11854421, ECO:0000269PubMed:16221885, ECO:0000269PubMed:17554592, ECO:0000269PubMed:17620405, ECO:0000269PubMed:17635584, ECO:0000269PubMed:21730289}.
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Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus. {ECO:0000269PubMed:11854421, ECO:0000269PubMed:16221885, ECO:0000269PubMed:17635584, ECO:0000269PubMed:21730289}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
41
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
10
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003994
Prefoldin-related, ubiquitously expressed transcript
IPR004127
Prefoldin alpha-like
IPR009053
Prefoldin
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PFAM |
PF02996
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PRINTS |
PR01502
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBK9
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PhosphoSite |
PhosphoSite-Q9UBK9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8409
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UniGene |
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RefSeq |
NP_705582
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HUGO |
HGNC:12641
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OMIM |
300234
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CCDS |
CCDS14284
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HPRD |
02209
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IMGT |
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EMBL |
AF083241
AF083242
AF092737
AK312072
AL009172
BC000720
BC008890
CH471164
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GenPept |
AAD28698
AAD39839
AAD39840
AAH00720
AAH08890
BAG35008
CAI42447
CAI42448
EAW59326
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