InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdyl

Summary

InnateDB Protein

IDBP-620134.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdyl

Protein Name

chromodomain protein, Y chromosome-like

Synonyms

AI325931;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131784

InnateDB Gene

IDBG-144790 (Cdyl)

Protein Structure

UniProt Annotation

Function

Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (By similarity). Has histone acetyltransferase activity. May play a role in histone hyperacetylation during spermatid maturation. {ECO:0000250, ECO:0000269PubMed:12072557, ECO:0000269PubMed:12947414}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12072557, ECO:0000269PubMed:12947414}.

Disease Associations

Tissue Specificity

Highly expressed in testis (at protein level). Expressed as 2 transcripts: a ubiquitous transcript and a highly expressed testis-specific transcript.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0003824	catalytic activity
GO:0004402	histone acetyltransferase activity
GO:0035064	methylated histone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008152	metabolic process
GO:0016573	histone acetylation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1339956

InterPro

IPR000953 Chromo domain/shadow
IPR001753 Crotonase superfamily
IPR016197 Chromo domain-like
IPR017984 Chromo domain subgroup
IPR023780 Chromo domain
IPR029045 ClpP/crotonase-like domain

PFAM

PF00378
PF00385

PRINTS

PR00504

PIRSF

SMART

SM00298

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt