InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmp6

Summary

InnateDB Protein

IDBP-620217.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmp6

Protein Name

bone morphogenetic protein 6

Synonyms

D13Wsu115e; Vgr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126999

InnateDB Gene

IDBG-145907 (Bmp6)

Protein Structure

UniProt Annotation

Function

Induces cartilage and bone formation. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the lung. Low levels seen in the kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0046982	protein heterodimerization activity
GO:0070700	BMP receptor binding

Biological Process

GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0001654	eye development
GO:0001822	kidney development
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001958	endochondral ossification
GO:0003323	type B pancreatic cell development
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0010039	response to iron ion
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014823	response to activity
GO:0030154	cell differentiation
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030539	male genitalia development
GO:0032026	response to magnesium ion
GO:0032332	positive regulation of chondrocyte differentiation
GO:0032349	positive regulation of aldosterone biosynthetic process
GO:0032526	response to retinoic acid
GO:0040007	growth
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051216	cartilage development
GO:0051384	response to glucocorticoid
GO:0060395	SMAD protein signal transduction
GO:0071260	cellular response to mechanical stimulus
GO:2000860	positive regulation of aldosterone secretion

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031988	membrane-bounded vesicle

Protein Structure and Domains

PDB ID

MGI:88182

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt