InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Xpo4

Summary

InnateDB Protein

IDBP-620327.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xpo4

Protein Name

exportin 4

Synonyms

B430309A01Rik; mKIAA1721;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133280

InnateDB Gene

IDBG-168721 (Xpo4)

Protein Structure

UniProt Annotation

Function

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0015031	protein transport
GO:0046827	positive regulation of protein export from nucleus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1888526

InterPro

IPR016024 Armadillo-type fold

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ESJ0

PhosphoSite

PhosphoSite-Q9ESJ0

TrEMBL

UniProt Splice Variant

Entrez Gene

57258

UniGene

Mm.407626

RefSeq

NP_065252

MGI ID

MGI Symbol

Xpo4

OMIM

CCDS

CCDS56961

HPRD

IMGT

EMBL

AC154504 AC154675 AF145021 AK129430

GenPept

AAG09133 BAC98240