Version 5.4
Mus musculus Protein: Tifa
Summary
InnateDB Protein IDBP-620675.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tifa
Protein Name TRAF-interacting protein with forkhead-associated domain
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000132309
InnateDB Gene IDBG-193164 (Tifa)
Protein Structure
UniProt Annotation
Function Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. {ECO:0000250UniProtKB:Q96CG3, ECO:0000269PubMed:11798190}.
Subcellular Localization
Disease Associations
Tissue Specificity Highly expressed in the spleen and at lower levels in heart, brain, lung, liver, kidney and testes. {ECO:0000269PubMed:11798190, ECO:0000269PubMed:12566447}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
Cellular Component
Protein Structure and Domains
PDB ID MGI:2182965
InterPro IPR000253 Forkhead-associated (FHA) domain
IPR008984 SMAD/FHA domain
PFAM PF00498
PRINTS
PIRSF
SMART SM00240
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q793I8
PhosphoSite PhosphoSite-Q793I8
TrEMBL I3PQW8
UniProt Splice Variant
Entrez Gene 211550
UniGene Mm.404642
RefSeq XP_006501300
MGI ID
MGI Symbol Tifa
OMIM
CCDS CCDS38628
HPRD
IMGT
EMBL AB062111 AK041891 AK044221 AK149408 AK149864 AK151651 AK166239 BC065775 CH466532 JQ664736
GenPept AAH65775 AFE61896 BAB86903 BAC31825 BAE28856 BAE29133 BAE30580 BAE38653 BAE43315 EDL12255 EDL12256 EDL12257

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca