InnateDB Protein
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IDBP-620677.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tifa
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Protein Name
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TRAF-interacting protein with forkhead-associated domain
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000126692
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InnateDB Gene
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IDBG-193164 (Tifa)
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Protein Structure
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Function |
Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. {ECO:0000250UniProtKB:Q96CG3, ECO:0000269PubMed:11798190}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Highly expressed in the spleen and at lower levels in heart, brain, lung, liver, kidney and testes. {ECO:0000269PubMed:11798190, ECO:0000269PubMed:12566447}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2182965
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InterPro |
IPR000253
Forkhead-associated (FHA) domain
IPR008984
SMAD/FHA domain
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PFAM |
PF00498
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PRINTS |
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PIRSF |
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SMART |
SM00240
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TIGRFAMs |
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Modification |
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SwissProt |
Q793I8
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PhosphoSite |
PhosphoSite-Q793I8
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TrEMBL |
I3PQW8
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UniProt Splice Variant |
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Entrez Gene |
211550
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UniGene |
Mm.404642
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RefSeq |
XP_006501300
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MGI ID |
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MGI Symbol |
Tifa
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OMIM |
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CCDS |
CCDS38628
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HPRD |
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IMGT |
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EMBL |
AB062111
AK041891
AK044221
AK149408
AK149864
AK151651
AK166239
BC065775
CH466532
JQ664736
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GenPept |
AAH65775
AFE61896
BAB86903
BAC31825
BAE28856
BAE29133
BAE30580
BAE38653
BAE43315
EDL12255
EDL12256
EDL12257
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