InnateDB Protein
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IDBP-62090.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SNRNP70
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Protein Name
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small nuclear ribonucleoprotein 70kDa (U1)
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Synonyms
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RNPU1Z; RPU1; Snp1; SNRP70; U1-70K; U170K; U1AP; U1RNP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000221448
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InnateDB Gene
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IDBG-62088 (SNRNP70)
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Protein Structure
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Function |
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
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Subcellular Localization |
Nucleus. Nucleus speckle {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 133 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
133
[view]
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Protein-Protein |
133
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR022023
U1 small nuclear ribonucleoprotein of 70kDa N-terminal
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PFAM |
PF00076
PF12220
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
P08621
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PhosphoSite |
PhosphoSite-P08621
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TrEMBL |
Q9UFS1
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UniProt Splice Variant |
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Entrez Gene |
6625
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UniGene |
Hs.467097
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RefSeq |
NP_001287998
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HUGO |
HGNC:11150
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OMIM |
180740
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CCDS |
CCDS74417
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HPRD |
01617
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IMGT |
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EMBL |
AC008687
AK096783
AL117399
AL117507
BC000342
BC001315
CH471177
M22636
M57929
M57930
M57932
M57934
M57935
M57937
M57939
X04654
X06811
X06812
X06814
X06815
X06816
X06817
X07401
X07402
X07403
X84841
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GenPept |
AAA03001
AAA36571
AAA36572
AAA36573
AAH00342
AAH01315
BAG53365
CAA28352
CAA29960
CAA29961
CAA29963
CAA29964
CAA29965
CAA29966
CAA30303
CAA30304
CAA30305
CAA59278
CAB55900
CAB55969
EAW52449
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