InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pla2g6

Summary

InnateDB Protein

IDBP-620967.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pla2g6

Protein Name

phospholipase A2, group VI

Synonyms

BB112799; iPLA(2)beta; iPLA2; iPLA2beta; PNPLA9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134456

InnateDB Gene

IDBG-161414 (Pla2g6)

Protein Structure

UniProt Annotation

Function

Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform Long: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes. {ECO:0000250}.Isoform Short: Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0043008	ATP-dependent protein binding
GO:0047499	calcium-independent phospholipase A2 activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006629	lipid metabolic process
GO:0006935	chemotaxis
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007613	memory
GO:0008152	metabolic process
GO:0014832	urinary bladder smooth muscle contraction
GO:0016042	lipid catabolic process
GO:0032049	cardiolipin biosynthetic process
GO:0034976	response to endoplasmic reticulum stress
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045909	positive regulation of vasodilation
GO:0045921	positive regulation of exocytosis
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060135	maternal process involved in female pregnancy
GO:0090037	positive regulation of protein kinase C signaling
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0090238	positive regulation of arachidonic acid secretion
GO:1901339	regulation of store-operated calcium channel activity
GO:2000304	positive regulation of ceramide biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1859152

InterPro

IPR002110 Ankyrin repeat
IPR002641 Patatin/Phospholipase A2-related
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF01734
PF11929
PF12796

PRINTS

PR01415

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt