InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tfe3

Summary

InnateDB Protein

IDBP-621575.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfe3

Protein Name

transcription factor E3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134125

InnateDB Gene

IDBG-129438 (Tfe3)

Protein Structure

UniProt Annotation

Function

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. {ECO:0000269PubMed:16936731}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:16936731}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006959	humoral immune response
GO:0045670	regulation of osteoclast differentiation
GO:0045785	positive regulation of cell adhesion
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter