InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nsmce2

Summary

InnateDB Protein

IDBP-621818.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nsmce2

Protein Name

non-SMC element 2 homolog (MMS21, S. cerevisiae)

Synonyms

1110014D18Rik; AI661537;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128893

InnateDB Gene

IDBG-144259 (Nsmce2)

Protein Structure

UniProt Annotation

Function

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity

Biological Process

GO:0000722	telomere maintenance via recombination
GO:0000724	double-strand break repair via homologous recombination
GO:0007067	mitotic nuclear division
GO:0016925	protein sumoylation
GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion
GO:0045842	positive regulation of mitotic metaphase/anaphase transition
GO:0090398	cellular senescence