InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tpx2

Summary

InnateDB Protein

IDBP-622066.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpx2

Protein Name

TPX2, microtubule-associated protein homolog (Xenopus laevis)

Synonyms

2610005B21Rik; DIL2; p100; REPP86;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128888

InnateDB Gene

IDBG-209892 (Tpx2)

Protein Structure

UniProt Annotation

Function

Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:18663142}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:18663142}. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0006915	apoptotic process
GO:0007067	mitotic nuclear division
GO:0032147	activation of protein kinase activity
GO:0060236	regulation of mitotic spindle organization

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton
GO:0043203	axon hillock