InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIP4K2A

Summary

InnateDB Protein

IDBP-62251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIP4K2A

Protein Name

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

Synonyms

PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA; PIPK;

Species

Homo sapiens

Ensembl Protein

ENSP00000365757

InnateDB Gene

IDBG-62249 (PIP4K2A)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. {ECO:0000269PubMed:18364242}.

Subcellular Localization

Cell membrane {ECO:0000250}. Nucleus {ECO:0000269PubMed:20583997}. Cytoplasm {ECO:0000269PubMed:20583997}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. {ECO:0000269PubMed:7639683, ECO:0000269PubMed:7852364}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016307	phosphatidylinositol phosphate kinase activity
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0035855	megakaryocyte development
GO:0044281	small molecule metabolic process
GO:0046488	phosphatidylinositol metabolic process
GO:0046854	phosphatidylinositol phosphorylation