InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppip5k2

Summary

InnateDB Protein

IDBP-622934.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppip5k2

Protein Name

diphosphoinositol pentakisphosphate kinase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132889

InnateDB Gene

IDBG-184574 (Ppip5k2)

Protein Structure

UniProt Annotation

Function

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. {ECO:0000269PubMed:17690096}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0000832	inositol hexakisphosphate 5-kinase activity
GO:0003993	acid phosphatase activity
GO:0005524	ATP binding
GO:0033857	diphosphoinositol-pentakisphosphate kinase activity
GO:0052723	inositol hexakisphosphate 1-kinase activity
GO:0052724	inositol hexakisphosphate 3-kinase activity