InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTTN

Summary

InnateDB Protein

IDBP-62316.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTTN

Protein Name

cortactin

Synonyms

EMS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000365745

InnateDB Gene

IDBG-62310 (CTTN)

Protein Structure

UniProt Annotation

Function

Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases. {ECO:0000269PubMed:16636290, ECO:0000269PubMed:21296879}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	137 [view]
Protein-Protein	137 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005938	cell cortex
GO:0030027	lamellipodium
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome
GO:1990023	mitotic spindle midzone