InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pacsin2

Summary

InnateDB Protein

IDBP-623370.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pacsin2

Protein Name

protein kinase C and casein kinase substrate in neurons 2

Synonyms

AI197433;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130098

InnateDB Gene

IDBG-168133 (Pacsin2)

Protein Structure

UniProt Annotation

Function

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. {ECO:0000269PubMed:11082044, ECO:0000269PubMed:15930129, ECO:0000269PubMed:20188097, ECO:0000269PubMed:21610094, ECO:0000269PubMed:21693584, ECO:0000269PubMed:21807942, ECO:0000269PubMed:23129763}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane {ECO:0000250}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.

Disease Associations

Tissue Specificity

Widely expressed (at protein level). {ECO:0000269PubMed:10431838, ECO:0000269PubMed:11082044}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008289	lipid binding
GO:0042802	identical protein binding
GO:0070300	phosphatidic acid binding

Biological Process

GO:0007165	signal transduction
GO:0030036	actin cytoskeleton organization
GO:0036010	protein localization to endosome
GO:0045806	negative regulation of endocytosis
GO:0048858	cell projection morphogenesis
GO:0070836	caveola assembly
GO:0072584	caveolin-mediated endocytosis
GO:0097320	membrane tubulation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005901	caveola
GO:0005911	cell-cell junction
GO:0019898	extrinsic component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0032587	ruffle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome