InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfatc1

Summary

InnateDB Protein

IDBP-624077.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfatc1

Protein Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Synonyms

2210017P03Rik; AI449492; AV076380; NF-ATc; NFAT2; NFATc; Nfatcb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126884

InnateDB Gene

IDBG-161489 (Nfatc1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	9 [view]
Protein-DNA	16 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001837	epithelial to mesenchymal transition
GO:0006355	regulation of transcription, DNA-templated
GO:0006816	calcium ion transport
GO:0007507	heart development
GO:0010628	positive regulation of gene expression
GO:0030316	osteoclast differentiation
GO:0035556	intracellular signal transduction
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:102469

InterPro

IPR002909 IPT domain
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set

PFAM

PF01833
PF00554

PRINTS

PR01789

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt