InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apoe

Summary

InnateDB Protein

IDBP-624087.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apoe

Protein Name

apolipoprotein E

Synonyms

AI255918;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133371

InnateDB Gene

IDBG-152108 (Apoe)

Protein Structure

UniProt Annotation

Function

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008201	heparin binding
GO:0008289	lipid binding
GO:0016209	antioxidant activity
GO:0017127	cholesterol transporter activity
GO:0042803	protein homodimerization activity
GO:0046848	hydroxyapatite binding
GO:0046911	metal chelating activity
GO:0046982	protein heterodimerization activity
GO:0048156	tau protein binding
GO:0050750	low-density lipoprotein particle receptor binding
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070326	very-low-density lipoprotein particle receptor binding
GO:0071813	lipoprotein particle binding

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0002021	response to dietary excess
GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006707	cholesterol catabolic process
GO:0006869	lipid transport
GO:0006874	cellular calcium ion homeostasis
GO:0006898	receptor-mediated endocytosis
GO:0006979	response to oxidative stress
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007263	nitric oxide mediated signal transduction
GO:0007568	aging
GO:0008203	cholesterol metabolic process
GO:0010468	regulation of gene expression
GO:0010544	negative regulation of platelet activation
GO:0010873	positive regulation of cholesterol esterification
GO:0010875	positive regulation of cholesterol efflux
GO:0019934	cGMP-mediated signaling
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0032489	regulation of Cdc42 protein signal transduction
GO:0032526	response to retinoic acid
GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0032868	response to insulin
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034380	high-density lipoprotein particle assembly
GO:0034382	chylomicron remnant clearance
GO:0034384	high-density lipoprotein particle clearance
GO:0034447	very-low-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0042158	lipoprotein biosynthetic process
GO:0042159	lipoprotein catabolic process
GO:0042311	vasodilation
GO:0042632	cholesterol homeostasis
GO:0043407	negative regulation of MAP kinase activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0043691	reverse cholesterol transport
GO:0045471	response to ethanol
GO:0045541	negative regulation of cholesterol biosynthetic process
GO:0045773	positive regulation of axon extension
GO:0048709	oligodendrocyte differentiation
GO:0048844	artery morphogenesis
GO:0050728	negative regulation of inflammatory response
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051651	maintenance of location in cell
GO:0055088	lipid homeostasis
GO:0071347	cellular response to interleukin-1
GO:0071363	cellular response to growth factor stimulus
GO:0071397	cellular response to cholesterol
GO:0072358	cardiovascular system development

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0030425	dendrite
GO:0031232	extrinsic component of external side of plasma membrane
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0042627	chylomicron
GO:0043025	neuronal cell body