InnateDB Protein
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IDBP-624170.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fez1
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Protein Name
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fasciculation and elongation protein zeta 1 (zygin I)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000126072
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InnateDB Gene
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IDBG-149600 (Fez1)
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Protein Structure
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Function |
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with both, alpha- and gamma- tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
54 [view]
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Molecular Function |
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Biological Process |
GO:0006810
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transport
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GO:0010976
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positive regulation of neuron projection development
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GO:0045666
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positive regulation of neuron differentiation
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GO:0051654
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establishment of mitochondrion localization
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GO:0071363
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cellular response to growth factor stimulus
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Cellular Component |
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PDB ID |
MGI:2670976
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InterPro |
IPR011680
Fasciculation and elongation protein zeta, FEZ
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PFAM |
PF07763
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K0X8
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PhosphoSite |
PhosphoSite-Q8K0X8
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TrEMBL |
Q3UU92
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UniProt Splice Variant |
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Entrez Gene |
235180
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UniGene |
Mm.5264
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RefSeq |
NP_898994
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MGI ID |
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MGI Symbol |
Fez1
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OMIM |
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CCDS |
CCDS40581
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HPRD |
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IMGT |
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EMBL |
AK138656
BC029629
CT009699
CT955982
DQ141674
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GenPept |
AAH29629
AAZ74351
BAE23735
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