InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccrn4l

Summary

InnateDB Protein

IDBP-624957.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccrn4l

Protein Name

CCR4 carbon catabolite repression 4-like (S. cerevisiae)

Synonyms

AU043840; Ccr4; nocturnin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130347

InnateDB Gene

IDBG-142661 (Ccrn4l)

Protein Structure

UniProt Annotation

Function

Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos. {ECO:0000269PubMed:17400819, ECO:0000269PubMed:20498072, ECO:0000269PubMed:20685873, ECO:0000269PubMed:21820310, ECO:0000269PubMed:22073225, ECO:0000269PubMed:22082366, ECO:0000269PubMed:22331129, ECO:0000269PubMed:23449310}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, perinuclear region.

Disease Associations

Tissue Specificity

Highly expressed in the differentiated adipocyte (at protein level). Ubiquitous. {ECO:0000269PubMed:10521507, ECO:0000269PubMed:11394964, ECO:0000269PubMed:20392228}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006397	mRNA processing
GO:0007623	circadian rhythm
GO:0009991	response to extracellular stimulus
GO:0010629	negative regulation of gene expression
GO:0032496	response to lipopolysaccharide
GO:0032922	circadian regulation of gene expression
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0042752	regulation of circadian rhythm
GO:0045600	positive regulation of fat cell differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045995	regulation of embryonic development
GO:0048255	mRNA stabilization
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic