InnateDB Protein
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IDBP-625359.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cd209b
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Protein Name
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CD209b antigen
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Synonyms
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1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7; SIGNR1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000126070
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InnateDB Gene
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IDBG-130726 (Cd209b)
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Protein Structure
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Function |
Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in skin, spleen and lung, probably in a subset of dendritic cells. Detected in spleen extrafollicular paracortical areas including the red pulp and marginal zones, and at lower levels, in the follicular area. Detected in skin suprabasal areas adjacent to the epidermis and in epidermal cell layer. {ECO:0000269PubMed:12137941}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916415
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InterPro |
IPR001304
C-type lectin
IPR002353
Type-2 ice-structuring protein
IPR016187
C-type lectin fold
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PFAM |
PF00059
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PRINTS |
PR00356
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CJ91
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
69165
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UniGene |
Mm.175163
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RefSeq |
NP_001032889
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MGI ID |
3ZHG
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MGI Symbol |
Cd209b
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OMIM |
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CCDS |
CCDS22076
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HPRD |
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IMGT |
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EMBL |
AF373409
AF374471
AF422108
AF424790
AF424791
AF424792
AF424793
AF424794
AF424795
AF424796
AF424797
AF424798
AF424799
AF424800
AF424801
AF424802
AK007656
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GenPept |
AAL13235
AAL27540
AAN31450
AAN75585
AAN75586
AAN75587
AAN75588
AAN75589
AAN75590
AAN75591
AAN75592
AAN75593
AAN75594
AAN75595
AAN75596
AAN75597
BAB25166
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