Homo sapiens Protein: RANBP9 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-62536.5 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | RANBP9 | ||||||||||||||||||||||
Protein Name | RAN binding protein 9 | ||||||||||||||||||||||
Synonyms | BPM-L; BPM90; RanBP7; RANBPM; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000011619 | ||||||||||||||||||||||
InnateDB Gene | IDBG-62534 (RANBP9) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm, cytosol. Nucleus. Note==Predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells. {ECO:0000269PubMed:12147692, ECO:0000269PubMed:12361945, ECO:0000269PubMed:15381419}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR001870
B30.2/SPRY domain IPR003877 SPRY domain IPR006594 LisH dimerisation motif IPR006595 CTLH, C-terminal LisH motif IPR008985 Concanavalin A-like lectin/glucanases superfamily IPR013144 CRA domain IPR013720 LisH dimerisation motif, subgroup IPR024964 CTLH/CRA C-terminal to LisH motif domain |
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PFAM |
PF00622
PF08513 PF10607 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00449
SM00667 SM00668 SM00757 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q96S59 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q96S59 | ||||||||||||||||||||||
TrEMBL | B2R8E1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 10048 | ||||||||||||||||||||||
UniGene | Hs.732354 | ||||||||||||||||||||||
RefSeq | NP_005484 | ||||||||||||||||||||||
HUGO | HGNC:13727 | ||||||||||||||||||||||
OMIM | 603854 | ||||||||||||||||||||||
CCDS | CCDS4529 | ||||||||||||||||||||||
HPRD | 04835 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB008515 AB055311 AF306510 AK313334 AL441883 BC019886 BC052781 BC063849 CH471087 Z93020 | ||||||||||||||||||||||
GenPept | AAH19886 AAH52781 AAH63849 AAK15469 BAA23216 BAB62525 BAG36138 CAI19841 CAI21594 EAW55341 EAW55345 | ||||||||||||||||||||||