InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nf2

Summary

InnateDB Protein

IDBP-625489.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nf2

Protein Name

neurofibromatosis 2

Synonyms

merlin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129388

InnateDB Gene

IDBG-142996 (Nf2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001707	mesoderm formation
GO:0006469	negative regulation of protein kinase activity
GO:0007398	ectoderm development
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0021766	hippocampus development
GO:0031647	regulation of protein stability
GO:0042127	regulation of cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043409	negative regulation of MAPK cascade
GO:0045216	cell-cell junction organization
GO:0045597	positive regulation of cell differentiation
GO:1900180	regulation of protein localization to nucleus
GO:2000177	regulation of neural precursor cell proliferation

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005912	adherens junction
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030864	cortical actin cytoskeleton
GO:0032154	cleavage furrow
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:97307

InterPro

IPR000299 FERM domain
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain

PFAM

PF09379
PF09380
PF00373

PRINTS

PIRSF

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9PW99

UniProt Splice Variant

Entrez Gene

18016

UniGene

RefSeq

XP_006514637

MGI ID

MGI Symbol

Nf2

OMIM

CCDS

HPRD

IMGT

EMBL

AL606521 AL645603

GenPept