InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pfdn5

Summary

InnateDB Protein

IDBP-625898.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pfdn5

Protein Name

prefoldin 5

Synonyms

1190001O17Rik; 1700010A06Rik; D15Ertd697e; Eig1; MM-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129178

InnateDB Gene

IDBG-188389 (Pfdn5)

Protein Structure

UniProt Annotation

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060041	retina development in camera-type eye
GO:0090090	negative regulation of canonical Wnt signaling pathway