Version 5.4
Homo sapiens Protein: GET4
Summary
InnateDB Protein IDBP-6268.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GET4
Protein Name golgi to ER traffic protein 4 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265857
InnateDB Gene IDBG-406617 (GET4)
Protein Structure
UniProt Annotation
Function Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting. {ECO:0000269PubMed:20676083}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:20676083}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0008150 biological_process
GO:0071816 tail-anchored membrane protein insertion into ER membrane
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
GO:0071818 BAT3 complex
Protein Structure and Domains
PDB ID
InterPro IPR007317 Uncharacterised protein family UPF0363
PFAM PF04190
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7L5D6
PhosphoSite PhosphoSite-Q7L5D6
TrEMBL C9JPA8
UniProt Splice Variant
Entrez Gene 51608
UniGene Hs.611288
RefSeq NP_057033
HUGO HGNC:21690
OMIM 612056
CCDS CCDS5317
HPRD 12909
IMGT
EMBL AC073957 AC099731 AF132954 AK024305 AK097899 AK125863 AL133014 BC003550 CH236965 CH471144
GenPept AAD27729 AAH03550 BAG51289 BAG53546 BAG54258 CAB61355 EAL23708 EAW87179 EAW87180

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca