InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il7

Summary

InnateDB Protein

IDBP-626946.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il7

Protein Name

interleukin 7

Synonyms

A630026I06Rik; hlb368; Il-7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126219

InnateDB Gene

IDBG-130583 (Il7)

Protein Structure

UniProt Annotation

Function

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005139	interleukin-7 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0002360	T cell lineage commitment
GO:0006955	immune response
GO:0010468	regulation of gene expression
GO:0030890	positive regulation of B cell proliferation
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0045582	positive regulation of T cell differentiation
GO:0046622	positive regulation of organ growth
GO:0048873	homeostasis of number of cells within a tissue
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand