InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sv2b

Summary

InnateDB Protein

IDBP-627063.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sv2b

Protein Name

synaptic vesicle glycoprotein 2 b

Synonyms

A830038F04Rik; AI850768; mKIAA0735;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127245

InnateDB Gene

IDBG-192965 (Sv2b)

Protein Structure

UniProt Annotation

Function

Probably plays a role in the control of regulated secretion in neural and endocrine cells. {ECO:0000250}.Receptor for the botulinium neurotoxin type A/BOTA. {ECO:0000269PubMed:10624962, ECO:0000269PubMed:16543415}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin- secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in ribbon synapses of the retina (at protein level). {ECO:0000269PubMed:12687700}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006836	neurotransmitter transport
GO:0007268	synaptic transmission
GO:0055085	transmembrane transport

Cellular Component

GO:0001669	acrosomal vesicle
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane

Protein Structure and Domains

PDB ID

MGI:1927338

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
IPR022308 Synaptic vesicle protein SV2

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BG39

PhosphoSite