InnateDB Protein
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IDBP-62797.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCNL1
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Protein Name
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cyclin L1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000295926
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InnateDB Gene
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IDBG-62795 (CCNL1)
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Protein Structure
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Function |
Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21. {ECO:0000269PubMed:11980906, ECO:0000269PubMed:12414649, ECO:0000269PubMed:15700036}.
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Subcellular Localization |
Nucleus speckle {ECO:0000250}. Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). {ECO:0000269PubMed:11980906, ECO:0000269PubMed:12414649, ECO:0000269PubMed:15700036}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000079
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regulation of cyclin-dependent protein serine/threonine kinase activity
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006396
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RNA processing
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Cellular Component |
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PDB ID |
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InterPro |
IPR006671
Cyclin, N-terminal
IPR013763
Cyclin-like
IPR017060
Cyclin L
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PFAM |
PF00134
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PRINTS |
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PIRSF |
PIRSF036580
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SMART |
SM00385
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UK58
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PhosphoSite |
PhosphoSite-Q9UK58
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57018
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UniGene |
Hs.734304
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RefSeq |
NP_064703
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HUGO |
HGNC:20569
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OMIM |
613384
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CCDS |
CCDS3178
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HPRD |
10814
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IMGT |
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EMBL |
AF180920
AF208843
AF367476
AF367477
AK022974
AY034790
AY358663
BC007081
BC038394
BC067812
CH471052
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GenPept |
AAD53184
AAF64257
AAH07081
AAH38394
AAH67812
AAK61551
AAM21204
AAM21205
AAQ89026
BAG51145
EAW78712
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