Version 5.4
Homo sapiens Protein: IL18BP
Summary
InnateDB Protein IDBP-62966.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL18BP
Protein Name interleukin 18 binding protein
Synonyms IL18BPa;
Species Homo sapiens
Ensembl Protein ENSP00000260049
InnateDB Gene IDBG-62960 (IL18BP)
Protein Structure
UniProt Annotation
Function Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. {ECO:0000269PubMed:10023777, ECO:0000269PubMed:10655506}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Strongly expressed in heart, lung, placenta and spleen. {ECO:0000269PubMed:10023777, ECO:0000269PubMed:10094485}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 3 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042007 interleukin-18 binding
GO:0048019 receptor antagonist activity
Biological Process
GO:0042088 T-helper 1 type immune response
GO:1900116 extracellular negative regulation of signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95998
PhosphoSite PhosphoSite-O95998
TrEMBL Q9UNH2
UniProt Splice Variant
Entrez Gene 10068
UniGene Hs.591967
RefSeq NP_001138529
HUGO HGNC:5987
OMIM 604113
CCDS CCDS8206
HPRD 04984
IMGT
EMBL AB019504 AF110798 AF110799 AF110800 AF110801 AF122906 AF122908 AF215907 AK098255 AP002490 BC044215 CH471076
GenPept AAD17187 AAD17188 AAD17189 AAD17190 AAD17191 AAD17192 AAD41051 AAD41053 AAF31697 AAH44215 BAA76374 BAG53602 EAW74813 EAW74816 EAW74817

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca