Version 5.4
Homo sapiens Protein: UNC50
Summary
InnateDB Protein IDBP-63016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC50
Protein Name unc-50 homolog (C. elegans)
Synonyms GMH1; UNCL; URP;
Species Homo sapiens
Ensembl Protein ENSP00000350409
InnateDB Gene IDBG-63014 (UNC50)
Protein Structure
UniProt Annotation
Function May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus inner membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000269PubMed:12808035}; Multi-pass membrane protein {ECO:0000269PubMed:12808035}.
Disease Associations
Tissue Specificity Present in periodontal ligament fibroblasts (at protein level). {ECO:0000269PubMed:17004066}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0015031 protein transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005637 nuclear inner membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007881 UNC-50
PFAM PF05216
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53HI1
PhosphoSite PhosphoSite-Q53HI1
TrEMBL
UniProt Splice Variant
Entrez Gene 25972
UniGene Hs.635345
RefSeq NP_054763
HUGO HGNC:16046
OMIM
CCDS CCDS2035
HPRD 18259
IMGT
EMBL AC010134 AC064860 AF077038 AK222599 AL080115 AY017215 AY251534 BC017019 BC025992 BC039078 BC091481 CH471127 CR533464
GenPept AAD27771 AAH17019 AAH25992 AAH39078 AAH91481 AAK08987 AAP20057 AAX93232 AAY14975 BAD96319 CAB45714 CAG38495 EAX01900 EAX01901 EAX01902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca