InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MITD1

Summary

InnateDB Protein

IDBP-63221.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MITD1

Protein Name

MIT, microtubule interacting and transport, domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000289359

InnateDB Gene

IDBG-63219 (MITD1)

Protein Structure

UniProt Annotation

Function

Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. {ECO:0000269PubMed:23015756, ECO:0000269PubMed:23045692}.

Subcellular Localization

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0035091	phosphatidylinositol binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000281	mitotic cytokinesis
GO:0000920	cytokinetic cell separation
GO:0032091	negative regulation of protein binding
GO:1902409	mitotic cytokinetic cell separation

Cellular Component

GO:0019898	extrinsic component of membrane
GO:0030496	midbody
GO:0031902	late endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome