Homo sapiens Protein: KIF13A | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-63491.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | KIF13A | ||||||||||||||||||
Protein Name | kinesin family member 13A | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000259711 | ||||||||||||||||||
InnateDB Gene | IDBG-63485 (KIF13A) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269PubMed:19841138, ECO:0000269PubMed:20208530}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane {ECO:0000250}. Note=Recruited to the midbody during cytokinesis. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Widely expressed, with highest levels in heart, brain and skeletal muscle. {ECO:0000269PubMed:11374900, ECO:0000269PubMed:11861365}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000253
Forkhead-associated (FHA) domain IPR001752 Kinesin, motor domain IPR008984 SMAD/FHA domain IPR022140 Kinesin protein 1B IPR022164 Kinesin-like IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00498
PF00225 PF12423 PF12473 |
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PRINTS |
PR00380
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PIRSF | |||||||||||||||||||
SMART |
SM00240
SM00129 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9H1H9 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9H1H9 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 63971 | ||||||||||||||||||
UniGene | Hs.94499 | ||||||||||||||||||
RefSeq | NP_071396 | ||||||||||||||||||
HUGO | HGNC:14566 | ||||||||||||||||||
OMIM | 605433 | ||||||||||||||||||
CCDS | CCDS47381 | ||||||||||||||||||
HPRD | 09256 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AJ291578 AJ291579 AL023807 AL138724 AY014403 AY014404 BC062673 BC127115 BC127116 | ||||||||||||||||||
GenPept | AAG38890 AAG38891 AAI27116 AAI27117 CAC20442 CAC20443 CAI21670 CAI21671 CAI40947 CAI40948 | ||||||||||||||||||