InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NMD3

Summary

InnateDB Protein

IDBP-63696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NMD3

Protein Name

NMD3 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000307525

InnateDB Gene

IDBG-63694 (NMD3)

Protein Structure

UniProt Annotation

Function

Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269PubMed:12724356, ECO:0000269PubMed:12773398}.

Subcellular Localization

Cytoplasm. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030674	protein binding, bridging
GO:0043023	ribosomal large subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000055	ribosomal large subunit export from nucleus
GO:0015031	protein transport

Cellular Component

GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR007064 NMD3

PFAM

PF04981

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96D46

PhosphoSite

PhosphoSite-Q96D46

TrEMBL

C9K0C2

UniProt Splice Variant

Entrez Gene

51068

UniGene

Hs.718722

RefSeq

NP_057022

HUGO

HGNC:24250

OMIM

611021

CCDS

CCDS3194

HPRD

13026

IMGT

EMBL

AC021649 AC108738 AF132941 AK296710 BC013317 CH471052

GenPept

AAD27716 AAH13317 BAG59303 EAW78618 EAW78619