InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HDAC6

Summary

InnateDB Protein

IDBP-63933.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC6

Protein Name

histone deacetylase 6

Synonyms

CPBHM; HD6; PPP1R90;

Species

Homo sapiens

Ensembl Protein

ENSP00000365804

InnateDB Gene

IDBG-63929 (HDAC6)

Protein Structure

UniProt Annotation

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000250}.In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Subcellular Localization

Nucleus. Cytoplasm. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=It is mainly cytoplasmic, where it is associated with microtubules.

Disease Associations

Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM) [MIM:300863]: A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild mental retardation. {ECO:0000269PubMed:20181727}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 303 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	303 [view]
Protein-Protein	250 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	47 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0031593	polyubiquitin binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0042826	histone deacetylase binding
GO:0042903	tubulin deacetylase activity
GO:0043014	alpha-tubulin binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048156	tau protein binding
GO:0051879	Hsp90 protein binding
GO:0070840	dynein complex binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006476	protein deacetylation
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0006886	intracellular protein transport
GO:0008152	metabolic process
GO:0009636	response to toxic substance
GO:0009967	positive regulation of signal transduction
GO:0010033	response to organic substance
GO:0010469	regulation of receptor activity
GO:0010634	positive regulation of epithelial cell migration
GO:0010727	negative regulation of hydrogen peroxide metabolic process
GO:0010870	positive regulation of receptor biosynthetic process
GO:0016236	macroautophagy
GO:0016575	histone deacetylation
GO:0032418	lysosome localization
GO:0034983	peptidyl-lysine deacetylation
GO:0035967	cellular response to topologically incorrect protein
GO:0043242	negative regulation of protein complex disassembly
GO:0045861	negative regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051354	negative regulation of oxidoreductase activity
GO:0051788	response to misfolded protein
GO:0060632	regulation of microtubule-based movement
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070301	cellular response to hydrogen peroxide
GO:0070842	aggresome assembly
GO:0070845	polyubiquitinated misfolded protein transport
GO:0070846	Hsp90 deacetylation
GO:0070848	response to growth factor
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0090035	positive regulation of chaperone-mediated protein complex assembly
GO:0090042	tubulin deacetylation
GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005901	caveola
GO:0016234	inclusion body
GO:0016235	aggresome
GO:0030286	dynein complex
GO:0030424	axon
GO:0030425	dendrite
GO:0031252	cell leading edge
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm